Endocrine Abstracts

Background: The Cushing’s disease (CD) is associated with comorbidities that have a significant impact on patients’ quality of life. However, it is not known the true impact of the disease remission on these comorbidities.Objectives: To assess the evolution of comorbidities associated with CD, after its remission.Methods: It was done an observational, analytical and retrospective study of patients with CD in remission, fo...

Introduction: Cyclic Cushing syndrome (CCS) involves rhythmic fluctuations in ACTH secretion resulting in a cyclic variation of adrenal steroid production.Case presentation: A 37-year-old woman was referred to our Pituitary Clinic in 1999, for evaluation of galactorrhea and irregular menses that had started four months ago. She also complained of depression, facial hirsutism, alopecia and progressive obesity. Blood pressure was normal. Endocrinological e...

Introduction: There are limited data on the incidence and prevalence of pituitary adenomas (PA). Although classically considered rare, systematic assessments from autopsy and radiological studies have shown a prevalence of 17% in the general population.Objective: We describe the epidemiologic of PA in Braga, the third most populous district of Portugal (860 000 inhabitants, 2673 km2), over the last 20 years.Methods: We r...

Introduction: Radiotherapy (RT) has been proven to be effective in controlling hormone production and tumor growth in pituitary adenomas (PA). Still, RT adverse effects had turned it an unattractive choice of treatment. The aim of this study was to evaluate the efficacy and safety of RT for patients with PA.Methods: We conducted a retrospective study of patients treated in our center, a central hospital, since 1998. Thirty-three patients were included, 6...

IntroductionPituitary apoplexy (PA) consists of acute infarction/hemorrhage of the gland, involving mostly a previously unrecognized adenoma. One of its most documented precipitating factors is anticoagulation in the context of acute coronary syndrome treatment. To our knowledge only one report described a PA secondary to anticoagulation for pulmonary thromboembolism.Case reportA 75-year-old men with known hy...

Background: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is associated with an increased cardiometabolic risk in adult life. Nevertheless, data regarding pediatric age is scarce. We aimed to evaluate cardiometabolic risk factors in patients with CAH due to 21-hydroxylase deficiency in pediatric age.Methods: We reviewed the clinical records of patients with CAH evaluated in a Pediatric Endocrinology Unit in a central hospital. Pat...

Introduction: The economic burden of obesity on healthcare systems is increasing. Bariatric surgery leads to considerable weight loss and health improvement. However, this surgery is costly and doubts about its affordability have been raised. Few studies have assessed outcomes such as drug use and costs after bariatric surgery. The aim of this study was to evaluate drug consumption and costs before and after bariatric surgery.Methods: Retrospectively, da...

Introduction: Hyperosmolar hyperglycaemic state (HHS) and diabetic ketoacidosis (DKA) are the two most serious acute metabolic complication of diabetes mellitus (DM). The authors propose to characterise the admissions for HHS and DKA at a univeristy hospital.Methods: An observational, descriptive, and retrospective study in adults admitted to the hospital between January 2009 and October 2013 due to HHS and DKA. The information was accessed via the patie...

Introduction: Diabetes mellitus (DM) is a major risk factor for stroke and has been shown that diabetic patients who suffer stroke have a worse prognosis, with greater morbidity and mortality.Objectives: Determination of the prevalence of DM in hospitalised patients for ischaemic stroke. Comparison of demographic variables, complications prevalence, length of hospital stay and in-hospital mortality among diabetic and non-diabetic patients. Assessment of ...

Introduction: Primary hyperaldosteronism (PA) is a disturbance caused by the autonomous production of aldosterone by the adrenal gland. The most frequent causes are due to bilateral supra-renal gland hyperplasia and aldesterone producing adenoma. It is most frequent amongst women aged between 30 and 50 years of age. It is clinically characterised by hypertension (HTN), resistant to therapy. Hypokalaemia, which is known as a ‘classical marker’ is found in less than a ...